CEN Toxicology Review

TCA Antidepressants

S/S: hyperthermia, tachycardia, hypertension, altered mental status, prolonged QTi, ventricular dysrhythmias, seizures.

TX: sodium bicarbonate, lidocaine, magnesium, benzodiazepines.

Sympathomimetics (Cocaine, methamphetamine, Molly)

S/S: euphoria, mydriasis, tachycardia, hyperthermia.

TX: benzodiazepines, sodium bicarbonate, phentolamine.

Sedatives/Benzodiazepine OD

S/S: respiratory depression, CNS depression, bradycardia.

TX: assist ABCs, flumazenil is no longer recommended for overdose since risk of seizures.

Opioids

S/S: respiratory depression is most concerning.

TX: Assist breathing and consider naloxone for opioid-induced respiratory depression.

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